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Can gum disease lead to Alzheimer’s? Study says it just might

For most, implants beat dentures, but at a price The New York Times

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If you needed another reason to brush and floss, maybe this will help. Researchers at New York University have found that gum disease may increase the risk of cognitive dysfunction associated with Alzheimer’s disease. This NYU study provides fresh evidence that gum inflammation is associated with inflammation
in the brain. The research team, led by Dr. Angela Kamer, assistant professor of periodontology and implant dentistry, studied 20 years of data from Denmark that support the hypothesis of a link between periodontal disease and Alzheimer’s. Morehttp://www.perio.org

Review Article

Periodontitis and risk for atherosclerosis: an update on intervention trials
Maurizio S. Tonetti 1
1 European Research Group on Periodontology (ERGOPERIO), Berne, Switzerland
Correspondence to Address : Maurizio S. Tonetti
European Research Group on Periodontology (ERGOPERIO) Berne Switzerland

E-mail: maurizio.tonetti@ergoperio.eu

Conflict of interest and source of funding statement
This paper has been presented at the New York Academy of Science, the 2008 Annual Meeting of the German Society of Periodontology and at symposia organized at the IADR-PEF meeting in London and at the FDI World Dental Congress in Stockholm Sweden in September 2008. These symposia were funded by Johnson & Johnson. The author received a speaking engagement fee and a fee for the preparation of this manuscript from Johnson & Johnson Ltd.

KEYWORDS
atherosclerosis • causality • controlled clinical trials • periodontitis • review

Tonetti MS. Periodontitis and risk for atherosclerosis: an update on intervention trials. J Clin Periodontol 2009; 36 (Suppl. 10): 15–19. doi: 10.1111/j.1600-051X.2009.01417.x.

Review Article

Aims: Periodontitis has been associated with an increased risk of cardiovascular events. The nature of the association is unclear because both periodontitis and cardiovascular disease (CVD) share a host of risk factors. Intervention trials are critical to explore the relationship. If the association were causal, successful periodontal therapy will lead to an attenuation of the effect – CVD.Material and Methods: The paper reviewed the design and the results of intervention trials aimed at improving systemic inflammation, endothelial dysfunction, carotid atherosclerosis and cardiovascular events.

Results: Early systematic reviews and a definitive controlled clinical trial indicate that intensive periodontal therapy results in a decrease in systemic inflammation and an improvement of endothelial dysfunction in systemically healthy subjects. A pilot trial has indicated the feasibility to assess the impact of periodontal therapy on carotid atherosclerosis in a primary cardiac prevention design.

Conclusions: Efforts to test causality in the relationship between periodontitis and CVD are ongoing.
Evidence to date is consistent with the notion that severe generalized periodontitis causes systemic inflammation and endothelial dysfunction. Periodontitis has effects that go beyond the oral cavity and its treatment and prevention may contribute to the prevention of atherosclerosis.

Accepted for publication 4 April 2009

Research

Platelet Rich Plasma to Facilitate Wound Healing Following Tooh Extraction

Following tooth removal bone formation normally takes 16 weeks and may result in less than adequate
volume for the necessary reconstruction. Platelet rich plasma (PRP) has been promoted as an effective
method for improving bone formation. Its use is often expensive, time consuming, or not clinically
convenient for the patient and/or clinician. This study examines a simple method for obtaining
a ‘‘Buffy Coat’’-PRP (BC-PRP) and its effect on bone healing following the removal of bilateral mandibular
3rd molars. Subtraction digital radiography and CT scan analysis were used to track changes in radiographic
density at PRP treated sites in comparison to ipsilateral non-PRP treated sites. PRP treated sites
demonstrated early and significant increased radiographic density over baseline measurements following
tooth removal. The greatest benefit of PRP is during the initial 2-week postoperative healing time period
(P , .001). During weeks 3 though 12, BC-PRP treatment resulted in significant (P , .0001) increases in bone
density compared to control,but there was no significant interaction between time and treatment (P . .05).
For the entire time period (0–25 weeks) PRP treatment was significant (P , .0001) and time was significant
(P , .0001) but there was no significant interaction (P . .05) between the effect of PRP treatment and time.
It required 6 weeks for control extraction sites to reach comparable bone density that PRP treated sites
achieved at week 1. Postoperative pain, bleeding, and numbness were not significantly affected by BC-PRP
application. Results suggest that this simple technique may be of value to clinicians performing oral surgery
by facilitating bone regeneration following tooth extraction.

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Research

An Analysis of a Rapid, Simple, and Inexpensive Technique Used to ObTain Platelet-Rich Plasma
For Use in Clinical Practice

The use of Platelet-rich plasma(PRP) has become more generally accepted,and implant dentists are
using Prp more frequently to promote the healing of oral surgical and/or periodontal wounds. Critical
elements of PRP are thought to be growth factors contained within the concentrated platelets. These
growth factors are known to promote soft-tissue healing, angiogenesis and osteogenesis. We present a
rapid,simple, and inexpensive methodology for preparing PRP usind the Cliniseal centrifuge method.
This study demonstrates that platelets are concentrated approximately6-fold without altering platelet
morphology. Further we demonstrate that key growth factor,platelet-derived growth factor BB(PDGFBB),
transforming growth factor B (TGF-B1), vasculature endothelial growth factor (VEGF), and epidermal growth
factor(EGF) are present in comparable or hihher concentrations than those reported with the use of other
techniques. Prolonged bench set time(>3 hours) after centrifugation resulted in decreased concentration
of TGF-B1 but not decreased concentration of PDGF-BB, VEGF, or EGF. This study confirms the molecular
aspects of PRP obtained using thia inexpensive and efficient methodology.

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